| Do., 08. Nov. 16:50 Uhr | ||||||
| Gr K | FK Astana | 2:1 (1:1) | FK Jablonec | |||
| Gr D | Fenerbahce Istanbul | 2:0 (0:0) | RSC Anderlecht | |||
| Do., 08. Nov. 18:55 Uhr | ||||||
| Gr J | Akhisarspor | 2:3 (0:2) | FC Sevilla | |||
| Gr H | Apollon Limassol | 2:3 (0:1) | Eintracht Frankfurt | |||
| Gr L | BATE Borissow | 0:1 (0:0) | FC Chelsea | |||
| Gr K | Dynamo Kiew | 3:1 (1:0) | FC Stade Rennes | |||
| Gr J | FK Krasnodar | 2:1 (0:1) | Standard Lüttich | |||
| Gr I | KRC Genk | 1:1 (0:1) | Besiktas Istanbul | |||
| Gr H | Lazio Rom | 2:1 (1:0) | Olympique Marseille | |||
| Gr L | Videoton FC | 1:0 (0:0) | PAOK Saloniki | |||
| Gr I | Malmö FF | 1:1 (0:0) | Sarpsborg 08 | |||
| Gr G | SK Rapid Wien | 0:0 (0:0) | FC Villarreal | |||
| Gr G | Spartak Moskau | 4:3 (2:3) | Glasgow Rangers | |||
| Do., 08. Nov. 21:00 Uhr | ||||||
| Gr E | FC Arsenal | 0:0 (0:0) | Sport. Lissabon | |||
| Gr A | Bayer Leverkusen | 1:0 (0:0) | FC Zürich | |||
| Gr C | Girondins Bordeaux | 1:1 (1:0) | St. Petersburg | |||
| Gr B | Celtic Glasgow | 2:1 (1:0) | RB Leipzig | |||
| Gr D | GNK Dinamo Zagreb | 3:1 (2:0) | Spartak Trnava | |||
| Gr A | Ludogorez Rasgrad | 0:0 (0:0) | AEK Larnaka | |||
| Gr F | Olympiakos | 5:1 (4:0) | F91 Düdelingen | |||
| Gr F | Betis Sevilla | 1:1 (1:0) | AC Mailand | |||
| Gr B | Rosenborg Trondheim | 2:5 (0:4) | Red Bull Salzburg | |||
| Gr C | SK Slavia Prag | 0:0 (0:0) | FC Køpenhagen | |||
| Gr E | Vorskla Poltava | 0:1 (0:1) | FK Qarabag | |||