| Do., 13. Dez. 18:55 Uhr | ||||||
| Gr J | Akhisarspor | 0:0 | Standard Lüttich | |||
| Gr I | Besiktas Istanbul | 0:1 | Malmö FF | |||
| Gr K | Dynamo Kiew | 0:1 | FK Jablonec | |||
| Gr I | KRC Genk | 4:0 | Sarpsborg 08 | |||
| Gr H | Lazio Rom | 1:2 | Eintracht Frankfurt | |||
| Gr L | Videoton FC | 2:2 | FC Chelsea | |||
| Gr H | Olympique Marseille | 1:3 | Apollon Limassol | |||
| Gr L | PAOK Saloniki | 1:3 | BATE Borissow | |||
| Gr K | FC Stade Rennes | 2:0 | FK Astana | |||
| Gr G | SK Rapid Wien | 1:0 | Glasgow Rangers | |||
| Gr J | FC Sevilla | 3:0 | FK Krasnodar | |||
| Gr G | FC Villarreal | 2:0 | Spartak Moskau | |||
| Do., 13. Dez. 21:00 Uhr | ||||||
| Gr A | AEK Larnaka | 1:5 | Bayer Leverkusen | |||
| Gr E | FC Arsenal | 1:0 | FK Qarabag | |||
| Gr B | Celtic Glasgow | 0:2 | Red Bull Salzburg | |||
| Gr D | GNK Dinamo Zagreb | 0:0 | RSC Anderlecht | |||
| Gr F | F91 Düdelingen | 0:0 | Betis Sevilla | |||
| Gr C | FC Køpenhagen | 0:1 | Girondins Bordeaux | |||
| Gr A | Ludogorez Rasgrad | 1:1 | FC Zürich | |||
| Gr F | Olympiakos | 3:1 | AC Mailand | |||
| Gr B | RB Leipzig | 1:1 | Rosenborg Trondheim | |||
| Gr C | SK Slavia Prag | 2:0 | St. Petersburg | |||
| Gr D | Spartak Trnava | 1:0 | Fenerbahce Istanbul | |||
| Gr E | Sport. Lissabon | 3:0 | Vorskla Poltava | |||