| Di., 12. Feb. 18:55 Uhr | ||||
| Fenerbahce Istanbul | 1:0 | St. Petersburg | ||
| Do., 14. Feb. 18:55 Uhr | ||||
| BATE Borissow | 1:0 | FC Arsenal | ||
| FK Krasnodar | 0:0 | Bayer Leverkusen | ||
| Galatasaray Istanbul | 1:2 | Benfica | ||
| Lazio Rom | 0:1 | FC Sevilla | ||
| Olympiakos | 2:2 | Dynamo Kiew | ||
| FC Stade Rennes | 3:3 | Betis Sevilla | ||
| SK Rapid Wien | 0:1 | Inter Mailand | ||
| SK Slavia Prag | 0:0 | KRC Genk | ||
| Do., 14. Feb. 21:00 Uhr | ||||
| Celtic Glasgow | 0:2 | FC Valencia | ||
| Club Brügge | 2:1 | Red Bull Salzburg | ||
| Malmö FF | 1:2 | FC Chelsea | ||
| Shakhtar Donezk | 2:2 | Eintracht Frankfurt | ||
| Sport. Lissabon | 0:1 | FC Villarreal | ||
| Vik. Plzen | 2:1 | GNK Dinamo Zagreb | ||
| FC Zürich | 1:3 | SSC Neapel | ||